Literaturverzeichnis

Allegra V, Mengozzi G, Martimbianco L, Vasile A: Glucose-induced insulin secretion in uremia: relation with acid-base balance and effects of bicarbonate administration. Nephron. 1993; 63(1):43–8.

Arnett T: Regulation of bone cell function by acidbase balance. Proc Nutr Soc. 2003; 62(2):11–20.

Astrup PB, Severinghaus JW: The History of Blood Gases, Acids and Bases. Copenhagen: Munksgaard; 1986: 332 S.

Balakrishnan S, Gopalakrishnan M, Alagesan M, Prakash ES: What is the ultimate goal in acid-base regulation? Adv Physiol Educ. 2007; 31:51–54.

Barela TD, Johnson JD, Hayek A: Metabolic Acidosis in the Newborn Period. Clin Endo Metab. 1983; 12:29.

Bassett CAL; Becker RO: Generation of electric potentials in bone in response to mechanical stress: Science. 1962; 137: 1063–1064.

Bellingham AJ, Detter JC, Lenfant C: The role of hemoglobin affinity for oxygen and red-cell 2,3-diphosphoglycerate in the management of diabetic ketoacidosis. Trans Assoc Am Physicians. 1970; 83:113–20.

Beynen AC, Buechler KF, van der Molen AJ, Geelen MJ: Inhibition of hepatic lipogenesis by salicylate. Toxicology. 1982; 24(1): 33–43.

Bors W, Büttner GR: The vitamin C radical and its reactions in Vitamin C in Health and Disease. New York: Dekker. 1997: 75-94.

Bredle DL, Stager JM, Brechue WF, Farber MO: Phosphate supplementation, cardiovascular function, and exercise performance in humans. J Appl Physiol. 1988; 65: 1821–1826.

Büttner GR. Ascorbate oxidation: UV absorbance of ascorbate and ESR spectroscopy of the ascorbyl radical as assays for iron. Free Rad Res Comm. 1990; 10:5–9.

Büttner GR: In the absence of catalytic metals, ascorbate does not autoxidize at pH 7: Ascorbate as a test for catalytic metals. J Biochem Biophys Meth. 1988; 16:20–40.

Bucher JR, Tien M, Aust SD: The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron. Biochem. Biophys. Res. Commun. 1983 ; 111:777–784.

Cade R, Conte M, Zauner C, Mars D, Peterson J, Lunne D, Hommen N, Packer D: Effects of phosphate loading on 2,3-diphosphoglycerate and maximal oxygen uptake. Med Sci Sports Exerc. 1984; 16: 263–268.

Chasiotis D: Role of cyclic AMP and inorganic phosphate in the regulation of muscle glycogenolysis during exercise. Med Sci Sports Exerc. 1988; 20: 545–550.

Chen LQ, Shepherd AP: Role of H+ and alpha 2-receptors in escape from sympathetic vasoconstriction. Am J Physiol Heart Circ Physiol. 1991; 261(H868-H873): 0363-6135.

Christen HR: Chemie. 11. Aufl. Diesterweg: Frankfurt/M; 1977:

Cooper DJ, Walley KR, Wiggs BR, Russell JA: Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study. Ann Intern Med. 1990; 112:92–8.

Dale G, Fleetwood J, Weddell A, Ellis R: Fitness, unfitness, and phosphate. Brit Med J, 1987; 294: 939.

Darby T, Aldinger EE, Gadsen RH, Throwers WB: Effects of metabolic acidosis on ventricular isometric systolic tension and the response to epinephrine and levarterenol. Circulat. Res. 1960; 8:1242.

Davis BD: On the Importance of Being Ionized. Arch Biochem Biophys. 1958; 78:497.

Demaurex N: pH-Homeostasis of Cellular Organelles. News Physiol. Sci. 2002; 17 (1): 1–5.

Demaurex N, Furuya W, D’Souza S, Bonifacino JS, Grinstein S: Mechanism of acidification of the trans-Golgi network (TGN). In situ measurements of pH using retrieval of TGN38 and furin from the cell surface. J Biol Chem. 1998; 273:2044–2051.

English P, Williams G: Hyperglycaemic crises and lactic acidosis in diabetes mellitus. Postgraduate Medical Journal. 2004; 80: 253–261.

Farinas J, Verkman A S: Receptor-mediated targeting of fluorescent probes in living cells. J Biol Chem. 1999; 274:7603–7606.

Frassetto L, Sebastian A: Age and systemic acid-base equilibrium. J Gerontol. 1996; 51A:B91 – B99.

Fishberg EH, Biermann W: Acid-Base Balance in Sweat. Journal of Biological Chemistry. 1932; 97(22): 433–441.

Galloway SDR, Tremblay MS, Sexsmith JR, Roberts CJ: The effects of acute phosphate supplementation in subjects of different aerobic fitness levels: European Journal of Applied Physiology. 1996; 72(3): 224–230.

Gao J, Costill DL, Horswill CA, Park SH: Sodium bicarbonate ingestion improves performance in interval swimming: European Journal of Applied Physiology. 1988; 58(1–2): 171–174.

Geinoz S, Guy RH, Testa B, Carrupt PA: Quantitative Structure-Permeation Relationships (QSPeRs) to Predict Skin Permeation: A Critical Evaluation. Pharm Res. 2004; 1: 83–92.

Glaesel, KO: Heilung ohne Wunder und Nebenwirkungen, Gesundheit biologisch gesteuert. Konstanz: Glaesel; 1993/1994: 272-277.

Glaser N, Barnett P, McCaslin I, Nelson D, Trainor J, Louie J, Kaufman F, Quayle K, Roback M, Malley R, Kuppermann N: Risk factors for cerebral edema in children with diabetic ketoacidosis. N Engl J Med. 2001; 344:264–9.

Goerge KP, MacLaren DPM: The effect of induced alkalosis and acidosis on endurance running at an intensity corresponding to 4mM blood lactate. Ergonomics. 1988; 31: 1639–1645.

Gonzales NC, Cingolani HE, Mattiazza AR, Marsiglia JC, Serur JE: Mechanism of action of Tris Aminomethane on the negative inotropic effect of carbon dioxide. Circulat. Res. 1971; 28:74.

Green SM, Rothrock SG, Ho JD:. Failure of adjunctive bicarbonate to improve outcome in severe pediatric diabetic ketoacidosis. Ann Emerg Med. 1998; 31:41–8.

Haddy FJ, Scott JB: Bioassay and other evidence for participation of chemical factors in local regulation of blood flow. Circulat. Res. 1971; 28(Supp. 1):86.

Heine H: Lehrbuch der Biologischen Medizin. Grundlagen und Extrazelluläre Matrix. 3. Aufl. Stuttgart: Hippokrates; 2006, 238 S.

Horswill CA, Costill DL, Fink WJ, Flynn MG, Kirwan JP: Influence of sodium bicarbonate on sprint performance: relationship to dosage. Med. Sci. Sports Exerc. 1988; 20: 556-569.

Inbar O, Rotstein A, Jacobs I et al: The efforts of alkaline treatments on short term maximal exercise. J Sports Sciences. 1983 ; 1: 95–104.

Kemmler W, Engelke K, Weineck J, Hensen J, Kalender WA: The Erlangen Fitness Osteoporosis Prevention Study: a controlled exercise trial in early postmenopausal women with low bone density-first-year results. Arch Phys Med Rehabil. 2003; 84(5): 673–82.

Kim JH, Lingwood CA, Williams DB, Furuya W, Manolson MF, Grinstein S: Dynamic measurement of the pH of the Golgi complex in living cells using retrograde transport of the verotoxin receptor. J Cell Biol. 1996; 134:1387–1399.

Kornak U, Delling G, Mundlos S: Molekulare Mechanismen der Regulation der Knochendichte durch Osteoklasten. Deutsches Ärzteblatt. 2003; 100(19):A–1258.

Kreider RB, Miller GW, Williams MH, Somma CT, Nasser T: Effects of phosphate loading on oxygen uptake, ventilatory anaerobic threshold, and run performance. Med Sci Sports Exerc. 1990; 22: 250–255.

Kreider RB, Almada AL, Antonio J, Broeder C, Earnest C, Greenwood M, Incledon T, Kalman DS, Kleiner SM, Leutholtz B, Lowery LM, Mendel R, Stout JR, Willoughby DS, Ziegenfuss TN: ISSN Exercise and Sport Nutrition Review: Research & Recommendations. Sports Nutrition Review Journal. 2004; 1(1): 1–44.

Laheij RJF; Sturkenboom MCJM; Hassing RJ; Dieleman J; Stricker BHC; Jansen JBMJ: Risk of Community-Acquired Pneumonia and Use of Gastric Acid – Suppressive Drugs. JAMA. 2004; 292:1955–1960.

Lehninger AL, Nelson DL, Cox MM: Lehninger Biochemie. 3. Aufl. Berlin: Springer; 2001: 1342 S.

Leveque N, Robin S, Muret P, Mac-Mary S, Makki S, Humbert P: High Iron and Low Ascorbic Acid Concentrations in the Dermis of Atopic Dermatitis Patients. Dermatology. 2003; 207:261–264.

Lever E, Jaspan JB: Sodium bicarbonate therapy in severe diabetic ketoacidosis. Am J Med. 1983; 75:263–8.

Llopis J, McCaffery JM, Miyawaki A, Farquhar MG, Tsien RY:Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proc Natl Acad Sci USA. 1998; 95:6803–6808.

Lutz J: Calcium Balance and acid-base status of women as affected by increased proteinintake and by sodium bicarbonate ingestion. Am J Clin Nutr. 1984; 39: 281–288.

Mainwood, GW, Cechetto D: The effect of bicarbonate concentration on fatigue and recovery in isolated rat diaphragm muscle. Can. J. Pharm. 1980; 58: 624–632.

Mannix ET, Stager JM, Harris A, et al : Oxygen delivery and cardiac output during exercise following oral phosphate-glucose. Med Sci Sport Exerc. 1990; 22: 341–347.

May JM, Qu Z. Li X: Requirement for GSH in recycling of ascorbic acid in endothelial cells. Biochemical Pharmacology. 2002; 62(7):873–81.

Mc Carty MF: Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output. Medical hypotheses. 2005; 64(2):380–384.

Mckenzie DC, Coutts K, Stirling D, Hochen H, Kutcha G: Maximal work production following two levels of artificially induced metabolic alkalosis: J. Sports Sci. 1986; 4: 35–38.

Mendiratta S, Qu ZC, May JM: Enzyme-dependent ascorbate recycling in human erythrocytes: role of thioredoxin reductase. Free Radical Biology & Medicine. 1998; 25:221–8.

Miller BF, Lindinger MI, Fattor JA, Jacobs KA, LeBlanc PJ, Duong M, Heigenhauser GJF, Brooks GA: Hematological and acid-base changes in men during prolonged exercise with and without sodium-lactate infusion. J Appl Physiol. 2005; 98:856–865.

Miller DM, Aust SD: Iron Chelates and Unwanted Biological Oxidations. Arch. Biochem. Biophys. 1988; 271: 113–119.

Miller GW, Kreider RB, Schenck D, Cortes CW, Miriel V, Crosson D: Effects of phosphate loading on anaerobic threshold. Med Sci Sports Exerc. 1991; 23: 535.

Miller R, Boska M, Moussavi R, et al. 31P nuclear magnetic resonance studies of high energy phosphates and pH in human muscle fatigue: Comparison of aerobic and anaerobic exercise. J Clin Invest. 1988; 81: 1190–1196.

Minotti G, Aust SD: Redox cycling of iron and lipid peroxidation. Lipids. 1992; 27(3): 219–226.

Mohr KF: Lehrbuch der chemisch-analytischen Titrirmethode. Braunschweig: Viehweg; 1855: 395 S.

Morgan RM, Patterson MJ, Nimmo MA: Acute effects of dehydration on sweat composition in men during prolonged exercise in the heat. Acta Physiologica. 2004, 182(1): 37–43(7).

Morris LR, Murphy MB, Kitabchi AE: Bicarbonate therapy in severe diabetic ketoacidosis. Ann Intern Med. 1986; 105:836–40.

Noriko A, Rei F, Kumpei T, Masashige A: About of resistance exercise increases urinary calcium independently of osteoclastic activation in men. J. Appl. Physiol. 1997; 1159–1163.

Posner JB, Plum F: Spinal-fluid pH and neurologic symptoms in systemic acidosis. N Engl J Med. 1967; 277:605–13.

Pullman A, Pullman B: Quantum Biochemistry. New York: Academic press. 1963: 217, 707.

Rahn H: Gas transport from the external environment to the cell. Development of the Lung. London: Churchill. 1967, 3–23.

Reeves RB: An imidazole alphastat hypothesis for vertebrate acid-base regulation: tissue carbon dioxide content and body temperature in bullfrogs. Respir. Physiol. 1972; 14: 219–236.

Reeves RB: The interaction of body temperature and acid-base balance in ectothermic vertebrates. Annu. Rev. Physiol. 1976; 39: 559–586.

Reeves RB: Temperature-induced changes in blood acid-base status: pH and PCO2 in a binary buffer. J. appl. Physiol. 1976; 40: 752–761.

Reeves RB: Alphastat regulation of intracellular acid-base state? In: Gilles P (Hrsg.): Circulation, Respiration, and Metabolism. Berlin: Springer; 1985: 414–423.

Rebolledo OR, Hernandez RE, Zanetta AC, Gagliardino JJ: Insulin secretion during acid-base alterations. Am J Physiol Endocrinol Metab. 1978; 234:E426–E429.

Riley LJ, Cooper M, Narins RG: Alkali therapy of diabetic ketoacidosis: biochemical, physiologic, and clinical perspectives. Diabetes Metab Rev. 1989; 5:627–36.

Ritter JM, Doktor HS, Benjamin N: Paradoxical effect of bicarbonate on cytoplasmic pH. Lancet. 1990; 335:1243–6.

Rupp JC,Bartels RL, Zuelzer W, Fox EL, Clark RN: Effect of sodium bicarbonate ingestion on blood and muscle pH and exercise performance. Med. Sci. Sports Exerc. 1983; 15: 115.

Sander FF: Der Säure-Basen-Haushalt des menschlichen Organismus. 3. Aufl. Stuttgart: Hippokrates; 1999: 156 S.

Siegel HW, Downing SE: Contributions of coronary perfusion pressure, metabolic acidosis and adrenergic factors to the reduction of myocardial contractility during hemorrhagic shock in the cat. Circulat. Res. 1970; 27:875.

Siegenthaler W: Siegenthalers Differenzialdiagnose, Innere Krankheiten – vom Symptom zur Diagnose. 19. Aufl. Stuttgart: Thieme; 2005: 1133 S.

Silberschmid M, Saito SI, Smith LL: Circulatory effects of acute lactic acidosis in dogs prior to and after hemorrhage. Amer. J. Surg. 1966; 112:175.

Smellie WS, O'Donnell J, Davidson H, Couper J, Logue FC: Effects of changes in acid base and calcium concentration on fasting serum insulin, proinsulin, and glucose concentrations. J Clin Pathol. 1994; 47(11):982–985.

Soler NG, Bennett MA, Dixon K, FitzGerald MG, Malins JM: Potassium balance during treatment of diabetic ketoacidosis with special reference to the use of bicarbonate. Lancet. 1972; 2:665–7.

Stewart I, McNaughton L, Davies P, Tristram S: Phosphate loading and the effects of VO2maxin trained cyclists. Res Quart. 1990; 61: 80–84.

Sutton, JR, Jones NL, Toews CJ: Effect of pH on muscle glycolysis during exercise. Clin. Sci. 1981; 61: 331–338.

Tchapda LN, Trommer WE, Wolf A: Mechanisms of the 3-Hydroxyl-3-Methylglutaryl-Coenzyme A Reductase Inhibitor-Induced Myotoxicity in Human Skeletal Muscle Cell Cultures [Dissertation]. Kaiserslautern: Technische Universität Kaiserslautern; 2005.

Teti A, Blair HC, Schlesinger P, Grano M, Zambonin-Zallone A, Kahn AJ, Teitelbaum SL, Hruska KA: Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures. J Clin Invest. 1989; 84(3):773–780.

Thompson CH, Syme PD, Williams EM, Ledingham JG, Radda GK: Effect of bicarbonate administration on skeletal muscle intracellular pH in the rat: implications for acute administration of bicarbonate in man. Clin Sci. 1992; 82:559–64.

Tucker KL, Hannan MT, Kiel DP: The acid-base hypothesis: Diet and bone in the Framingham Osteoporosis Study. Eur J Nutr. 2001; 40(5): 231–7.

van Doren C: Benjamin Franklin. New York: Overseas Edition. 1938; 522 S.

van Limburg Stirum J: Der Säurebasenhaushalt – Diagnose- und Therapiekonzepte. DHZ. 2006; 3: 29–33.

van Limburg Stirum J: Osteoporose und saure Nahrung, was ist dran? Biologische Medizin. 2006; 1: 8–11.

Veragut U, Smith LL: Circulatory changes during prolonged respiratory acidosis in normal and haemorrhaged dogs. Surg. Gynec. Obstet. 1964; 119:513.

Vethanayagam JG, Green EH,. Rose RC, Bode AM: Glutathione-dependent ascorbate recycling activity of rat serum albumin. Free Radical Biology & Medicine. 1999; 26:1591–8.

Viallon A, Zeni F, Lafond P, Venet C, Tardy B, Page Y, Bertrand JC: Does bicarbonate therapy improve the management of severe diabetic ketoacidosis? Crit Care Med. 1999; 27:2690–3.

Wang H, Katz RL: Effects of changes in coronary blood pH on the heart. Circulat. Res. 1965; 17:114.

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Wilkes D, Gledhill N, Smyth R: Effect of induced metabolic alkalosis on 800-m racing time: Med. Sci. Sports Exerc. 1983; 15: 277–280.

Winter C, Schulz N, Giebisch N, Geibel J P, Wagner C A: Nongenomic stimulation of vacuolar H-ATPases in intercalated renal tubule cells by aldosterone: PNAS. 2004; 101(8): 2636–2641.

Worlitschek M: Die Praxis des Säure-Basen-Haushaltes. 5. Aufl. Stuttgart: Haug; 2003: 127 S.

Yeo M, Kim DK, Kim YB, Oh TY, Lee JE, Cho SW, Kim HC, Hahm KB: Selective induction of apoptosis with proton pump inhibitor in gastric cancer cells: Clin Cancer Res. 2004; 10(24): 8687–96.